Wednesday, May 4, 2011

Which point mutation is most common with respect to Rifampicin resistance in Mycobacterium tuberculosis


Which point mutation is most common with respect to Rifampicin resistance in Mycobacterium tuberculosis?

Respiratory Diseases - 1 Answers
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A Ser to Leu amino acid substitution at position 531 of the rpoB gene is most common in clinical isolates. Another common mutation is a His to Tyr substitution at position 526 of the rpoB gene. Most Rifampicin associated mutations are found in the rpoB gene, which encodes the beta-subunit of RNA polymerase



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Posted by Tuberculosis at 9:37 AM