Tuesday, November 8, 2011

What specific gene(s) caused M. tuberculosis to gain it's resistance


What specific gene(s) caused M. tuberculosis to gain it's resistance?
What are the characteristics of this organism, anything I can talk abut related to it, that would capture the attention of a microbiologist is great. So please help me discover those topics. Thanks.
Infectious Diseases - 1 Answers
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Mycobacterium tuberculosis in an interesting little organism. It's surface contains a lot of lipids, which make it hydrophobic (repels water). This not only makes it difficult to stain, but makes it difficult to disinfect with traditional methods. It is classified as an "acid-fast" organism because it requires a special staining technique. It divides very slowly (only once every 12-24 hours) which make clinical identification somewhat tricky. TB is a big factor in worldwide mortality, particularly, with the advent of the AIDS/HIV virus. So, I do not know the specifics, but I know that most genes responsible for antibiotic resistances are located on "plasmids" which are circular chromosomes located outside the bacteriums primary chromosome. Bacteria, particularly closely related species have a primitive form of sexual reproduction during which they switch around plasmids. Developing antibacterial resistance is basically a form of evolution


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