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M. tuberculosis Comes from the genus Mycobacterium,which is composed of approximately 100 recognized and proposed species. The most familiar of the species are Mycobacterium tuberculosis and Mycobacterium leprae(Leprosy)(Page 576;Textbook of Diagnostic Microbiology, Mahon, Lehman, Manuselis). M. tuberculosis appears to be genetically diverse. A genetic diversity results in significant phenotypic differences between clinical isolates. M. tuberculosis exhibits a biogeographic population structure and different strain lineages are associated with different geographic regions. Phenotypic studies suggest that this strain variation never has implications for the development of new diagnostics and vaccines. Micro-evolutionary variation affects the relative fitness and transmission dynamics of antibiotic-resistant strains. In other words it evolved over time and has successfully changed enough to fight every vaccine and still be the classical TB virus/pathogen
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