When using Rifampin to treat TB, we can’t always expect successful results because some strains of M. tuberculosis have gained resistance to it. Specifically “in the 81-bp core region of rpoB gene, which encodes the B subunit of RNA polymerase†(J. Mendez p.1). I need help understanding what this mutation does specifically. I know what gene it affects, now I need to know the impact. Thanks.
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Does Rifampin not act by binding the beta subunit of RNA polymerase to prevent transcription? A mutation in the gene encoding this polymerase subunit results in a peptide sequence Rifampin cannot bind, reducing eliminating its action as a transcription inhibitor, depending upon the degree of mutated sequence dissimilarity with the correct sequence. Think of peptide sequences and affinity between binding proteins....when the chemical affinity is reduced between to species critical to a process (in this case, transcription inhibition), then the mechanism (in this case, transcription inhibition) is disrupted
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