Tuesday, June 28, 2011

what do they do when they test you for tuberculosis

what do they do when they test you for tuberculosis?
do they inject you with something or what? i have to get one for a program i am going in to...does it hurt? i need serious answers please. thanks!
Infectious Diseases - 3 Answers
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1 :
I had to get one for my internship at Kaiser. They give you a subcutaneous shot which is in your forearm. its a tiny needle that goes in the top layer of your skin and they inject the fluid and your skin gets a little bubble. It feels like a regular shot, just in your forearm. The bad part is that it leaves a mark for a week or so but eventually goes away.
2 :
Honestly, I have had about 4 of these for various positions. It's so on the surface, I usually can barely feel the needle. It will make a small rasied bump that will go away. Sometimes, it can itch, but you aren't supposed to scratch it, so the serum can do its thing. (And infection doesn't happen, it is somewhat of an open wound). The actual shot is super fast and you go back in 48 hours to have it "read." Generally, it's not that bad (at least I think so, and I hate needles!!!) Hope it helps!
3 :
Hi Kirsten, When I worked at group homes, homeless shelters, and the hospital, I had to do it. It is kind of freaky when they first inject the fluid under your skin. they don't always explain that it is normal for it to puff up like there is a bubble under your skin, and the first time I was positive that meant I had TB!!!! Anyway, usually the next day it goes down and just looks like a red spot which may or may not be lumpy. The next day, when you can go to any health clinic or hospital and have the results read, which means a nurse looks at it, it will not be bothering you at all. I hope you are going to a good program or nursing internship. Hope that helps. Post again if your skin reaction is freaking you out. It seems that most of us have had it done before, so you will get great responses



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Friday, June 24, 2011

How does a Tuberculosis survive

How does a Tuberculosis survive?
What does it eat? What is the shape? Where are they found? What do they do to survive? I am very interested, but I can't seem to find an exact answer on any websites. Yes, I know that Tubercualosis is a disease, but I am talking about the bacterium. Just answer as much as you know, please. Thank you very much!
Biology - 1 Answers
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1 :
This is a job for Wiki. Look up <http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis



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Monday, June 20, 2011

POLL/SURVEY: Is it only a matter of time before Tuberculosis becomes Drug-Resistant enough and kills us all

POLL/SURVEY: Is it only a matter of time before Tuberculosis becomes Drug-Resistant enough and kills us all?
Every time we come up with an antibiotic for TB, a new and more drug-resistant strain appears :( Will there ever be a point where Tuberculosis becomes powerful enough to become totally unstoppable, wiping us humans off the face of the earth?
Polls & Surveys - 3 Answers
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1 :
yeah i've heard that.
2 :
no.
3 :
My father had TB in the 1950's and even though he was treated he died in 1975 from chest problems.They never said that it was TB that killed him but a testicle he had removed not long before he died was TB infected.It never left his body and these days it is making a return and often the doctors are too stupid to recognise the symptoms in the first instance without having to deal with a more powerful strain of TB



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Thursday, June 16, 2011

How does the Tuberculosis pathogen cause the harm. (This is for a project i am undertaking)

How does the Tuberculosis pathogen cause the harm. (This is for a project i am undertaking)?

Respiratory Diseases - 3 Answers
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1 :
TB infection begins when the mycobacteria reach the pulmonary alveoli, where they invade and replicate within alveolar macrophages.[22] The primary site of infection in the lungs is called the Ghon focus. Bacteria are picked up by dendritic cells, which do not allow replication, although these cells can transport the bacilli to local (mediastinal) lymph nodes. Further spread is through the bloodstream to the more distant tissues and organs where secondary TB lesions can develop in lung apices, peripheral lymph nodes, kidneys, brain, and bone.
2 :
TB infection begins when the mycobacteria reach the pulmonary alveoli, where they invade and replicate within alveolar macrophages.[22] The primary site of infection in the lungs is called the Ghon focus. Bacteria are picked up by dendritic cells, which do not allow replication, although these cells can transport the bacilli to local (mediastinal) lymph nodes. Further spread is through the bloodstream to the more distant tissues and organs where secondary TB lesions can develop in lung apices, peripheral lymph nodes, kidneys, brain, and bone.[23] All parts of the body can be affected by the disease, though it rarely affects the heart, skeletal muscles, pancreas and thyroid.[24] Tuberculosis is classified as one of the granulomatous inflammatory conditions. Macrophages, T lymphocytes, B lymphocytes and fibroblasts are among the cells that aggregate to form a granuloma, with lymphocytes surrounding the infected macrophages. The granuloma functions not only to prevent dissemination of the mycobacteria, but also provides a local environment for communication of cells of the immune system. Within the granuloma, T lymphocytes (CD4+) secrete cytokines such as interferon gamma, which activates macrophages to destroy the bacteria with which they are infected.[25] T lymphocytes (CD8+) can also directly kill infected cells.[22] Importantly, bacteria are not always eliminated within the granuloma, but can become dormant, resulting in a latent infection. Another feature of the granulomas of human tuberculosis is the development of cell death, also called necrosis, in the center of tubercles. To the naked eye this has the texture of soft white cheese and was termed caseous necrosis.[26] If TB bacteria gain entry to the bloodstream from an area of damaged tissue they spread through the body and set up many foci of infection, all appearing as tiny white tubercles in the tissues. This severe form of TB disease is most common in infants and the elderly and is called miliary tuberculosis. Patients with this disseminated TB have a fatality rate of approximately 20%, even with intensive treatment.[27] In many patients the infection waxes and wanes. Tissue destruction and necrosis are balanced by healing and fibrosis.[26] Affected tissue is replaced by scarring and cavities filled with cheese-like white necrotic material. During active disease, some of these cavities are joined to the air passages bronchi and this material can be coughed up. It contains living bacteria and can therefore pass on infection. Treatment with appropriate antibiotics kills bacteria and allows healing to take place. Upon cure, affected areas are eventually replaced by scar tissue.[26
3 :
I have this medical condition as my skin condition. Which is why i agree with Matthias A and policetac. From what they put the information was quite informationable indeed for me too



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Sunday, June 12, 2011

Can I get tuberculosis if I use a condom

Can I get tuberculosis if I use a condom?
My new girlfriend has dormant tb. Will I still get tb if I use a condom? Is kissing her a bad idea? I haven't done anything with her...yet.
Infectious Diseases - 4 Answers
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1 :
Makes no difference if you use a condom, since TB is not spread through sexual contact. Contact with saliva and exhaled water droplets could be an issue - but see the info below. From the Wikipedia entry for TB - note the last line: = = = = = = When people suffering from active pulmonary TB cough, sneeze, speak, or spit, they expel infectious aerosol droplets 0.5 to 5 µm in diameter. A single sneeze can release up to 40,000 droplets. Each one of these droplets may transmit the disease, since the infectious dose of tuberculosis is very low and inhaling less than ten bacteria may cause an infection. People with prolonged, frequent, or intense contact are at particularly high risk of becoming infected, with an estimated 22% infection rate. A person with active but untreated tuberculosis can infect 10–15 other people per year. Others at risk include people in areas where TB is common, people who inject drugs using unsanitary needles, residents and employees of high-risk congregate settings, medically under-served and low-income populations, high-risk racial or ethnic minority populations, children exposed to adults in high-risk categories, patients immunocompromised by conditions such as HIV/AIDS, people who take immunosuppressant drugs, and health care workers serving these high-risk clients. Transmission can only occur from people with active — not latent — TB
2 :
First of all, tuberculosis isn't passed through sexual activity (it's not an STD). Secondly, a condom isn't a silver bullet to preventing pregnancy or contraction of STDs. People on here always say "we had sex but we used a condom and I still got herpes?! how did this happen?!" because they don't know that STDs do not need to be passed on through sex. They can be passed on through sex, kissing, oral sex, anal sex, sharing needles, biting, or simply by making contact with infected blood. So your junk might be wrapped, but if your girl has a canker-sore and you're making out, there's still some vulnerability there. Example, if you're playing football with someone that has AIDS, and you both have skinned knees (your knees are bleeding) and your blood mixes with his blood - there is a chance you can get AIDS. In all likelihood, the football example probably will not happen, but is possible. Anyways, so as far as your girl is concerned, you won't get tuberculosis, but at least I taught you something.
3 :
As TB is respiratory, transmitted by droplets from active TB, prophilactic condom would not help; I knew a grandma that lived with family and was dormant but she did not kiss anybody. And I don't recall she ever made conversation. There is a viraliant strong variety from Mexico and South America that is hard to control with usual USA TB medications. Hospitals and schools fired 3 that I know of for having dormant because of legal concerns I think. If a student or somebody came up positive, they MIGHT have gotten a lawyer and sued the school/hospitals. A jury of chosen ones would have awarded BIG money to the infected person out of fear of unknown. One of the TB dormants let cat out of the bag about the firings.
4 :
You can not catch TB in any way from your girlfriend if it is dormant, the condom is irrelevant. The bacteria is suppressed by her immune system in her lungs. The dormant bacteria may become active later in life if her immune system weakens by a medical condition or old age, then the bacteria may break through the immune systems protective capsule the bacteria is trapped in and become active



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Wednesday, June 8, 2011

How do they perform Tuberculosis Testing

How do they perform Tuberculosis Testing???
What kind of needle do they use?? Some people say they use a normal needle and some say it is like a little pricker. How do they test you for Tuberculosis?
Infectious Diseases - 7 Answers
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1 :
It's called a Mantoux TB test. They inject TB antigens (perfectly harmless) just under the surface of the skin and if you've had an infection before you will have a reaction to the antigen. This is because your body will already have the TB antibodies stored up from prior infection so they respond to the antigen. This causes extreme swelling in the testing area. As for the needle, it's very small and barely hurts at all. I get this tests every 3 months since I work in a laboratory neighboring a TB facility. They're really not all that bad. Hope that answers your question!
2 :
The TB skin test is done with a very tiny needle. It is intradermal test. The medication is placed right under the skin and the area is watched to see if in 72 hours a reaction ( red, raised patch) develops. If you are allergic to the TB skin test you may have a chest X-ray done instead.
3 :
T.B. test could be done by using any kind of needle. usuall they use a 4our headed pricker!!! don't worry it won't hurt at all. they have to put some dead T.B. under your skin to see if your body reacts to it. if it swells up after a day or two, that means your body was exposed to T.B. sometime during your life. If you are old and from 3rd world country, the chances are you were vaccinated for T.B. and that is why you test positive.
4 :
I've had it. The needle is pretty tiny. It's not like a regular shot but you can obviously still feel it
5 :
They use a very small needle, like the needles that diabetics use to give themselves insulin injections. They prick your forearm with the needle & inject the TB solution just under the skin to create a small bump. They give your body 48-72 hours ot react to it. If the bump goes away, then you have not been exposed. If the bump gets larger, you have at sometime been exposed, but this does not mean you have TB, so stay calm. You will from then on, need a chest X-ray instead of the test to be sure you do not have TB. RN
6 :
For a skin test, the normal way is with PPD (purified protein derivative). A very small amount of the fluid is injected just under the skin of the forearm with a tiny, thin needle. If you react to it, the area will become hard and raised. Redness alone doesn't mean a reaction is present. The other way - becoming very common - is a serum test. Your blood is drawn and a QuantiFERON test is done. This test is often done for healthcare workers, and those who work in housekeeping and food service in hospitals and nursing homes. The tine test, done with the little pricker, isn't very accurate so it isn't used much anymore.
7 :
There is the scratch test but by far the more commonly used is the Mantoux skin test which uses PPD (purified protein derivative). Many people mistakenly refer to the test as a "PPD". The usual needle size is 25g 5/8, which is 25 gauge, a small diameter, and 5/8 of an inch long, which is very short. Insulin needles come in a variety of gauges from 25 to 31. Tuberculin needles generally come in 25-27g and the needle is fixed to the syringe. You will have to define the word "normal" when referring to needles as all needles are normal to me. The protein is given as an intradermal injection on the inside of the left forearm. This is just below the surface of the skin and if done skillfully, will be painless. Even when not done skillfully, the sensation is a brief and minor pricking. What you usually (but not always) see afterward is what we call a "bleb", a small bubble created by the protein derivative. You'd be instructed to avoid wiping, rubbing and scratching the bleb. You'd also be instructed to return in 72 hours for a reading. Some places of employement require the two part Mantoux for high-risk folks in which the testing is perormed once and repeated in one week. Readings can be done from 48 to 72 hours but ideally it should be done as close to 72 hours as possible. If for some reason a person cannot return in 3 days, the site can be read in 48 hours. After 72 hours, the results are unreliable. The injection site may become red (this is called erythema). This is not a positive reaction. The injection site may swell (this is called induration). This isn't necessarily a positive reaction. The redness and induration, if there is any, will be measured. 0-4mm is insignificant and is a - result. 5-9mm is + in certain high-risk groups. 10-14mm is + in certain groups with preexisting conditions. 15 or greater is + in any group and any patient. A positive reaction does not indicate active TB but may indicate a previous exposure to the mycobacterium that causes it. You would, in this case, have a chest X-ray and possibly a sputum culture. The sputum culture has the final word. It's also called a sputum AFB, which stands for acid-fast bacilli, a reference to the bacterium and a culture that is postive indicates active TB. Once you have a positive Mantoux, you'll always have one and therefore you will not need to retested this way in the future. Instead, you would have a chest X-ray. If ever you were requested to have TB testing, you would want to speak up and make it clear that you must have a chest X-ray. The QuantiFERON-TB, or QFT, that was mentioned may be an alternative for some. It requires a blood draw but only one office visit instead of two. In this test your blood would be mixed with TB antigens and the interferon-gamma, produced in response to the mycobacterium antigen, would be measured to indicate positve or negative for TB. There are a few disadvantages to this testing. One is that it's reliability to differentiate between TB infection and TB disease hasn't been fully evaluated. Further diangostics would be required



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Saturday, June 4, 2011

Why does tuberculosis treatment require multiple drugs adminstered over a long period of time

Why does tuberculosis treatment require multiple drugs adminstered over a long period of time?

Infectious Diseases - 3 Answers
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1 :
TB has a high rate of drug resistance so it's important for doctors to assign you different drugs over a long period of time. Doctors would rather be safe and make sure all points are covered since advanced TB can be very deadly and contagious.
2 :
The drug is treating the virus which may lay latent for a while. Those drugs actually know this and so the drug will eventually get that virus.
3 :
Because some species of Mycobacterium tuberculosis are resistant to all/some anti-tubercular drugs and combinations of these drugs. Patients with MDR-TB(Multri-Drug Resistant TB) need a lung, or section removed. Tuberculosis treament requires multiple drugs because:: 1.) A patient taking drugs suddenly stops taking them, thus the M. tuberculosis strains are not all killed, and they develop resistant to that particular drug. 2.) The drug cannot bind to the bacterial cell walls 3.) The drug cannot pass through the cell membranes 4.) The drug is destroyed or inactivated by an enzyme 5.) The M. tuberculosis strain acquired a gene to produce an MDR pump, which pumps of the drugs before it can take effect



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