Saturday, June 4, 2011

Why does tuberculosis treatment require multiple drugs adminstered over a long period of time


Why does tuberculosis treatment require multiple drugs adminstered over a long period of time?

Infectious Diseases - 3 Answers
Random Answers, Critics, Comments, Opinions :
1 :
TB has a high rate of drug resistance so it's important for doctors to assign you different drugs over a long period of time. Doctors would rather be safe and make sure all points are covered since advanced TB can be very deadly and contagious.
2 :
The drug is treating the virus which may lay latent for a while. Those drugs actually know this and so the drug will eventually get that virus.
3 :
Because some species of Mycobacterium tuberculosis are resistant to all/some anti-tubercular drugs and combinations of these drugs. Patients with MDR-TB(Multri-Drug Resistant TB) need a lung, or section removed. Tuberculosis treament requires multiple drugs because:: 1.) A patient taking drugs suddenly stops taking them, thus the M. tuberculosis strains are not all killed, and they develop resistant to that particular drug. 2.) The drug cannot bind to the bacterial cell walls 3.) The drug cannot pass through the cell membranes 4.) The drug is destroyed or inactivated by an enzyme 5.) The M. tuberculosis strain acquired a gene to produce an MDR pump, which pumps of the drugs before it can take effect



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